Medicine information
Uses & overview
CARDULES ISMN SR 50 by Steris Healthcare contains 50 mg of Isosorbide Mononitrate in a specialized Sustained Release (SR) matrix. Engineered for high-potency daily anti-anginal protection, this oral organic nitrate provides a smooth, controlled release of active medication over an extended period, maintaining steady blood levels to prevent exertional chest pain while strategically guarding against nitrate tolerance. Key Uses & Clinical Benefits: Advanced Angina Pectoris Prevention: Effectively manages moderate to severe chronic stable chest pain episodes caused by narrowed coronary arteries. Sustained Release Technology: Formulated to release the drug continuously over several hours, ensuring consistent hemodynamic stability and preventing sudden blood pressure fluctuations. Reduces Myocardial Workload: Dilates peripheral veins and arteries, reducing venous return (preload) and systemic vascular resistance (afterload), which significantly decreases the heart's oxygen demand. Prevents Nitrate Tolerance: Formulated to support an eccentric once-daily dosing schedule that maintains an essential daily "nitrate-free interval" to preserve vascular responsiveness. Improves Functional Capacity: Enables patients with chronic stable angina to engage in daily physical activities with diminished chest discomfort and breathlessness. How CARDULES ISMN SR 50 Works: Isosorbide Mononitrate is metabolized to generate Nitric Oxide (NO) in vascular smooth muscle cells. Nitric oxide activates guanylate cyclase to increase intracellular cyclic Guanosine Monophosphate (cGMP), inducing vascular smooth muscle relaxation. This leads to marked venous dilation, reduced cardiac filling pressures, and enhanced blood delivery across collateral coronary vascular beds.
How to use
Take 1 tablet of CARDULES ISMN SR 50 once daily in the morning, or strictly as prescribed by your cardiologist or physician. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as doing so destroys the sustained-release delivery mechanism. Taking your dose consistently at the same time every morning ensures a natural nitrate-free period during rest and sleep hours.
Storage
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Store at a controlled room temperature below 30°C. Keep out of reach and sight of children.
