Medicine information
Uses & overview
GLISITAPTIN M 50/500 by Steris Healthcare brings together two complementary blood sugar-lowering agents: Sitagliptin Phosphate (50 mg) and Metformin Hydrochloride (500 mg). By combining a selective DPP-4 inhibitor with a biguanide, this dual-action formulation addresses multiple metabolic defects in type 2 diabetes—boosting glucose-dependent insulin release and enhancing insulin sensitivity in body tissues. Key Uses & Clinical Benefits: Synergistic Glycemic Regulation: Effectively lowers both fasting and postprandial (post-meal) blood glucose levels, helping patients achieve stable HbA1c targets. Incretin Enhancement: Sitagliptin (a DPP-4 inhibitor) prolongs the active life of naturally occurring incretin hormones (GLP-1 and GIP), boosting natural insulin secretion in response to food while suppressing excessive glucagon release. Reduces Hepatic Glucose Output: Metformin decreases glucose production in the liver, reduces intestinal absorption of glucose, and improves peripheral tissue sensitivity to insulin. Low Risk of Hypoglycemia: Works primarily through glucose-dependent mechanisms, providing high therapeutic safety and a low risk of blood sugar drops when used as directed. Weight-Neutral Profile: Designed to provide effective blood sugar management without causing body weight gain, supporting long-term metabolic health. How GLISITAPTIN M 50/500 Works: Sitagliptin Phosphate (50 mg): Prevents the enzymatic breakdown of incretin hormones by DPP-4, increasing mealtime insulin production and curbing excess glucagon output. Metformin Hydrochloride (500 mg): Activates AMP-activated protein kinase (AMPK) in hepatic tissue to suppress gluconeogenesis and optimize cellular response to circulating insulin.
How to use
Take 1 tablet of GLISITAPTIN M 50/500 twice daily with meals (preferably with breakfast and dinner) or strictly as prescribed by your physician. Taking the tablet with food helps reduce potential gastrointestinal upset associated with Metformin. Swallow the tablet whole with a glass of water.
Storage
Store in a cool, dry place away from direct sunlight, light, and moisture. Store at a controlled room temperature below 30°C. Keep out of reach and sight of children.
