Medicine information
Uses & overview
NEBIVALVE CILNI 2.5/10 by Steris Healthcare brings together two synergistic cardiovascular agents: Nebivolol Hydrochloride (2.5 mg) and Cilnidipine (10 mg). Designed to manage high blood pressure through complementary physiological mechanisms, this combination reduces peripheral vascular resistance, lowers cardiac workload, and protects target organs such as the heart and kidneys without causing reflex tachycardia or pedal edema (foot swelling). Key Uses & Clinical Benefits: Synergistic Blood Pressure Control: Delivers comprehensive 24-hour control over elevated systolic and diastolic blood pressure levels, helping prevent long-term cardiovascular events such as heart attacks and strokes. Cardio-Selective Beta-Blockade with Nitric Oxide Release: Nebivolol selectively blocks beta-1 adrenergic receptors while stimulating endothelial nitric oxide synthesis, promoting arterial vasodilation and improving endothelial function. Dual L/N-Type Calcium Channel Inhibition: Cilnidipine blocks both L-type calcium channels (in vascular smooth muscle) and N-type calcium channels (at sympathetic nerve endings), reducing sympathetic nerve activity and preventing reflex tachycardia. Renal Protective Properties: N-type calcium channel blockade dilates both afferent and efferent renal arterioles, reducing glomerular pressure and protecting kidney function—making it ideal for hypertensive patients with renal concerns or diabetes. Superior Side-Effect Profile: Significantly reduces common calcium channel blocker side effects such as ankle swelling (pedal edema) and maintains heart rate stability without causing lethargy or erectile dysfunction. How NEBIVALVE CILNI 2.5/10 Works: Nebivolol (2.5 mg): Decreases heart rate and cardiac contractility while promoting nitric oxide-mediated blood vessel dilation. Cilnidipine (10 mg): Prevents calcium influx into vascular smooth muscle cells and suppresses excessive norepinephrine release from sympathetic nerve terminals, causing smooth arterial relaxation and lowering blood pressure.
How to use
Take 1 tablet of NEBIVALVE CILNI 2.5/10 once daily, with or without food, or strictly as prescribed by your cardiologist or physician. Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet. Try to take your dose at the same time every day to maintain stable blood pressure regulation. Do not stop taking the medication abruptly without consulting your doctor.
Storage
Store in a cool, dry, and dark place away from direct sunlight, heat, and moisture. Maintain at a controlled room temperature below 30°C. Keep out of reach and sight of children.
